The ethics of adolescent decision making is a complicated mine­field with laws that vary from state to state. The case of a fourteen-year-old girl, who simultaneously was diagnosed with cancer and discovered she was pregnant, highlights several weaknesses in our current approach to adolescent decision making in the context of pregnancy. In addition, adolescents with life-limiting conditions face similar challenges that can be examined through the framework of Catholic doctrine.

Pediatric palliative care is specialized medical care for children who live with serious and life-limiting illnesses, with the central goal to improve quality of life for both children and their families. Presently, a majority of pediatric palliative care referrals are based on the traditional consultative model, in which primary providers serve as the gatekeepers to palliative care access. It is well-known that racial and ethnic healthcare disparities exist across the continuum of care, fraught with healthcare providers’ biases that impact the (...) care delivered. This includes the referral practices, allocation and utilization of palliative care services, and leaving vulnerable children and families with potentially unmet palliative care needs. We make the moral argument that the establishment of standard referral criteria for pediatric palliative care services is one simple step that must be taken to begin to address and hopefully ameliorate the impact of providers’ biases and disparities that exist within pediatric palliative care. (shrink)

We sometimes strive to achieve difficult goals when our evidence suggests that success is unlikely – not just because it will require strength of will, but because we are targets of prejudice and discrimination or because success will require unusual ability. Optimism about one’s prospects can be useful for persevering in these cases. That said, excessive optimism can be dangerous; when our evidence is unfavourable, we should be at most agnostic about whether we will succeed. This paper explores the nature (...) and rational significance of agnostic practical commitments. Most importantly, the rationality of striving against the odds can depend on investing in a plan for failure: a plan B. I aim to make headway on an account of what backup plans are, how they are related to primary plans, and whether the standard norms of plan rationality apply to our agnostic commitments. (shrink)

This discussion of Sergio Tenenbaum’s excellent book, Rational Powers in Action, focuses on two noteworthy aspects of the big picture. First, questions are raised about Tenenbaum’s methodology of giving primacy to cases in which the agent has all the requisite background knowledge, including knowledge of a means that will be sufficient for achieving her end, and no significant false beliefs. Second, the implications of Tenenbaum’s views concerning the rational constraints on revising our ends are examined.

Confabulation is a symptom central to many psychiatric diagnoses and can be severely debilitating to those who exhibit the symptom. Theorists, scientists, and clinicians have an understandable interest in the nature of confabulation—pursuing ways to define, identify, treat, and perhaps even prevent this memory disorder. Appeals to confabulation as a clinical symptom rely on an account of memory’s function from which cases like the above can be contrasted. Accounting for confabulation is thus an important desideratum for any candidate theory of (...) memory. Many contemporary memory theorists now endorse Constructivism, where memory is understood as a capacity for constructing plausible representations of past events. Constructivism’s aim is to account for and normalize the prevalence of memory errors in everyday life. Errors are plausible constructions that, on a particular occasion have led to error. They are not, however, evidence of malfunction in the memory system. While Constructivism offers an uplifting repackaging of the memory errors to which we are all susceptible, it has troubling implications for appeals to confabulation in psychiatric diagnosis. By accommodating memory errors within our understanding of memory’s function, Constructivism runs the risk of being unable to explain how confabulation errors are evidence of malfunction. After reviewing the literature on confabulation and Constructivism, respectively, I identify the tension between them and explore how different versions of Constructivism may respond. The paper concludes with a proposal for distinguishing between kinds of false memory—specifically, between misremembering and confabulation—that may provide a route to their reconciliation. (shrink)

Many of our most important goals require months or even years of effort to achieve, and some never get achieved at all. As social psychologists have lately emphasized, success in pursuing such goals requires the capacity for perseverance, or "grit." Philosophers have had little to say about grit, however, insofar as it differs from more familiar notions of willpower or continence. This leaves us ill-equipped to assess the social and moral implications of promoting grit. We propose that grit has an (...) important epistemic component, in that failures of perseverance are often caused by a significant loss of confidence that one will succeed if one continues to try. Correspondingly, successful exercises of grit often involve a kind of epistemic resilience in the face of failure, injury, rejection, and other setbacks that constitute genuine evidence that success is not forthcoming. Given this, we discuss whether and to what extent displays of grit can be epistemically as well as practically rational. We conclude that they can be (although many are not), and that the rationality of grit will depend partly on features of the context the agent normally finds herself in. In particular, grit-friendly norms of deliberation might be irrational to use in contexts of severe material scarcity or oppression. (shrink)

A substantial body of evidence shows that people tend to rely too heavily on explanations when trying to justify an opinion. Some research suggests these errors may arise from an inability to distinguish between explanations and the evidence that bears upon them. We examine an alternative account, that many people do distinguish between explanations and evidence, but rely more heavily on unsubstantiated explanations when evidence is scarce or absent. We examine the philosophical and psychological distinctions between explanation and evidence, and (...) show that participants use explanations as a substitute for missing evidence. Experiment 1 replicates the results of other researchers, but further shows that participants generate more evidence when they are not constrained by their lack of data. Merely mentioning a source of data can alter both their evaluation (Experiment 2) and their production (Experiment 3) of explanations and evidence. In Experiment 4, we show that participants can explicitly consider the availability of evidence and other pragmatic factors when evaluating arguments. Finally, we consider the implications of using explanations to replace missing evidence as a strategy in argument. (shrink)

The Archival and Constructive views of memory offer contrasting characterizations of remembering and its relation to memory errors. I evaluate the descriptive adequacy of each by offering a close analysis of one of the most prominent experimental techniques by which memory errors are elicited—the Deese-Roediger-McDermott paradigm. Explaining the DRM effect requires appreciating it as a distinct form of memory error, which I refer to as misremembering. Misremembering is a memory error that relies on successful retention of the targeted event. It (...) differs from both successful remembering and from confabulation errors, where the representation produced is wholly inaccurate. As I show, neither the Archival nor the Constructive View can account for the DRM effect because they are insensitive to misremembering’s unique explanatory demands. Fortunately, the explanatory limitations of the Archival and Constructive Views are complementary. This suggests a way.. (shrink)

Suppose some person 'A' sets out to accomplish a difficult, long-term goal such as writing a passable Ph.D. thesis. What should you believe about whether A will succeed? The default answer is that you should believe whatever the total accessible evidence concerning A's abilities, circumstances, capacity for self-discipline, and so forth supports. But could it be that what you should believe depends in part on the relationship you have with A? We argue that it does, in the case where A (...) is yourself. The capacity for "grit" involves a kind of epistemic resilience in the face of evidence suggesting that one might fail, and this makes it rational to respond to the relevant evidence differently when you are the agent in question. We then explore whether similar arguments extend to the case of "believing in" our significant others -- our friends, lovers, family members, colleagues, patients, and students. (shrink)

A substantial body of evidence shows that people tend to rely too heavily on explanations when trying to justify an opinion. Some research suggests these errors may arise from an inability to distinguish between explanations and the evidence that bears upon them. We examine an alternative account, that many people do distinguish between explanations and evidence, but rely more heavily on unsubstantiated explanations when evidence is scarce or absent. We examine the philosophical and psychological distinctions between explanation and evidence, and (...) show that participants use explanations as a substitute for missing evidence. Experiment 1 replicates the results of other researchers, but further shows that participants generate more evidence when they are not constrained by their lack of data. Merely mentioning a source of data can alter both their evaluation (Experiment 2) and their production (Experiment 3) of explanations and evidence. In Experiment 4, we show that participants can explicitly consider the availability of evidence and other pragmatic factors when evaluating arguments. Finally, we consider the implications of using explanations to replace missing evidence as a strategy in argument. (shrink)

G.E.M. Anscombe famously claimed that acting intentionally entails knowing "without observation" what one is doing. Among those that have taken her claim seriously, an influential response has been to suppose that in order to explain this fact, we should conclude that intentions are a species of belief. This paper argues that there are good reasons to reject this "cognitivist" view of intention in favor of the view that intentions are distinctively practical attitudes that are not beliefs and do not constitutively (...) involve the belief that one will do what one intends. A theory is then proposed on behalf of Distinctive Practical Attitude views of intention to explain Anscombe's non-observational knowledge phenomenon. It is argued that intentions do not embody non-observational knowledge, but they do provide the evidential basis for it: we know without observation what we are doing by inferring from our intentions. (shrink)

In Memory: A Philosophical Study, Bernecker argues for an account of contiguity. This Contiguity View is meant to solve relearning and prompting, wayward causation problems plaguing the causal theory of memory. I argue that Bernecker’s Contiguity View fails in this task. Contiguity is too weak to prevent relearning and too strong to allow prompting. These failures illustrate a problem inherent in accounts of memory causation. Relearning and prompting are both causal relations, wayward only with respect to our interest in specifying (...) remembering’s requirements. Solving them requires saying more about remembering, not causation. I conclude by sketching such an account. (shrink)

The idea that remembering involves an engram, becoming stable and permanent via consolidation, has guided the neuroscience of memory since its inception. The shift to thinking of memory as continuo...

There is a puzzle about how to understand the conclusion of a successful instance of practical reasoning. Do the considerations adduced in reasoning rationalize the particular doing of an action, as Aristotle is sometimes interpreted as claiming? Or does reasoning conclude in the formation of an attitude – an intention, say – that has an action-type as its content? This paper attempts to clarify what is at stake in that debate and defends the latter view against some of its critics.

How do we know what our intentions are? It is argued that work on self-knowledge has tended to neglect the attitude of intention, and that an epistemological account is needed that is attuned to the specific features of that state. Richard Moran’s Authorship view, on which we can acquire self-knowledge by making up our minds, offers a promising insight for such an account: we do not normally discover what we intend through introspection. However, his formulation of the Authorship view, developed (...) primarily with the attitude of belief in mind, is found wanting when applied to intention. An alternative account is proposed for knowledge of one’s own intentions that gives a central role to the mental act of deciding what to do. It is argued that we can come to know what we intend by making a decision about what to do and self-ascribing the content of that decision as our intended action. (shrink)

The anti-patriarchy movement is going to undo ten thousand years of recorded history…. You watch. The time has come. Women are gonna take charge of society.I think [#MeToo] will have staying power because people, and not only women, men as well as women, realize how wrong the behavior was and how it subordinated women. So we shall see, but my prediction is that it is here to stay.As the story is told, #MeToo arrived in a kairotic moment. Jodi Kantor and (...) Megan Twohey's 5 October 2017 New York Times exposé of the methods Harvey Weinstein used to systematically harass and subsequently silence women in the entertainment industry opened the proverbial floodgates. Ten days later, actor Alyssa... (shrink)

This paper discusses the possibility of autonomy in our epistemic lives, and the importance of the concept of the first person in weathering fluctuations in our epistemic perspective over time.

What is the role of practical thought in determining the intentional action that is performed? Donald Davidson’s influential answer to this question is that thought plays an efficient-causal role: intentional actions are those events that have the correct causal pedigree in the agent's beliefs and desires. But the Causal Theory of Action has always been plagued with the problem of “deviant causal chains,” in which the right action is caused by the right mental state but in the wrong way. This (...) paper addresses an alternative approach to understanding intentional action inspired by G.E.M. Anscombe, interpreting that view as casting practical thought in the role of formal rather than efficient cause of action and thereby avoiding the problem of deviant (efficient) causal chains. Specifically, on the neo-Anscombean view, it is the agent’s “practical knowledge” – non-observational, non-inferential knowledge of what one is doing – that confers the form of intentional action on an event and is the contribution of thought to determining what is intentionally done. This paper argues that the Anscombean view is subject to its own problematic type of deviance: deviant formal causation. What we know non-observationally about what we are doing often includes more than what we intend to be doing; we also know that we are bringing about the foreseen side effects of acting in the intended way. It is argued that the neo-Anscombean view faces difficulty in excluding the expected side effects from the specification of what is intentionally done, whereas the Causal Theory has no such difficulty. Thus, the discussion amounts to an argument in favor of the Causal Theory of Action. (shrink)

Optogenetics makes possible the control of neural activity with light. In this article, I explore how the development of this experimental tool has brought about methodological and theoretical advances in the neurobiological study of memory. I begin with Semon’s distinction between the engram and the ecphory, explaining how these concepts present a methodological challenge to investigating memory. Optogenetics provides a way to intervene into the engram without the ecphory that, in turn, opens up new means for testing theories of memory (...) error. I focus on a series of experiments where optogenetics is used to study false memory and forgetting. (shrink)

Is there a rational requirement enjoining continence over time in the intentions one has formed, such that anyone going in for a certain form of agency has standing reason to conform to such a requirement? This paper suggests that there is not. I argue that Michael Bratman’s defense of such a requirement succeeds in showing that many agents have a reason favoring default intention continence much of the time, but does not establish that all planning agents have such a reason (...) in every case of intending. I then defend an account on which such a reason is grounded in the need to maintain the capacity to commit oneself to a practical option. But although I think this applies more widely than Bratman’s account, it is also not a reason that any planning agent has in every case. I tentatively conclude that although we have many good reasons to stick with our intentions once we have formed them, it is not required by rationality. (shrink)

In her thought-provoking symposium contribution, ‘What Is Impostor Syndrome?’, Katherine Hawley fleshes out our everyday understanding of that concept. This response builds on Hawley’s account to ask the ameliorative question of whether the everyday concept best serves the normative goals of promoting social justice and enhancing well-being. I raise some sceptical worries about the usefulness of the notion, in so far as it is centred on doxastic attitudes that include doubt about one’s own talent or skill. I propose instead that (...) a narrower conception emphasizing the debilitating emotional and behavioural consequences of such beliefs might be preferable, and that the causes of such consequences would be better thought of as unjustified rather than false beliefs about one’s own competence. (shrink)

Constructivists about memory argue that memory is a capacity for building representations of past events from a generalized information store. The view is motivated by the memory errors discovered in cognitive psychology. Little has been known about the neural mechanisms by which false memories are produced. Recently, using a method I call the Optogenetic False Memory Technique, neuroscientists have created false memories in mice. In this paper, I examine how Constructivism fares in light of O-FaMe results. My aims are two-fold. (...) First, I argue that errors found in O-FaMe and cognitive psychology are similar behaviorally. Second, Constructivists should be able to explain the former since they purport to explain the latter, but they cannot. I conclude that O-FaMe studies reveal details about the mechanism by which false memories are produced that are incompatible with the explanatory approach to false memories favored by Constructivism. (shrink)

(2003). The Bioethics of Fiction: The Chimera in Film and Print. The American Journal of Bioethics: Vol. 3, No. 3, pp. 22-24. doi: 10.1162/15265160360706787.

School gardens and garden-based learning continue to gain great popularity in the United States, and their pedagogical potential, and ability to impact students’ fruit and vegetable consumption and activity levels have been well-documented. Less examined is their potential to be agents of food system reskilling and transformation. Though producer and consumer are inextricably linked in the food system, and deskilling of one directly influences the other, theorists often focus on production-centered and consumption-centered deskilling separately. However, in a school garden, the (...) production/consumption disconnect is erased, by virtue of the design of the site itself and how it is utilized by the actors within it. School gardens provide the critical component of education in alternative food networks, and contribute to the producer/consumer reskilling that is a necessary part of food system transformation. We conducted a case study of an established school garden program during its transition from autonomous non-profit to official, district-funded program of a rural school district in the Midwest. By participating in the full “seed to plate” life cycle of a garden crop, students in the garden were actively involved in the reconnection of producer and consumer, while educators were fostering in students an appreciation for fresh, healthy foods and actively challenging the “McDonaldization” of both students’ diets and education. Based upon these findings, we argue that school gardens in rural areas could leverage the dominant role of rural America in developing and shifting food system paradigms. (shrink)

In philosophical inquiry into the mind, the metaphor of ‘transparency’ has been attractive to many who are otherwise in deep disagreement. It has thereby come to have a variety of different and mutually incompatible connotations. The mind is said to be transparent to itself, our perceptual experiences are said to be transparent to the world, and our beliefs are said to be transparent to – a great many different things. The first goal of this essay is to sort out the (...) different uses of the notion of transparency in the context of the philosophy of mind. The remainder of the essay will then be devoted to examining so-called Transparency theories of self-knowledge, or how we know our own minds. This type of theory has attracted a great deal of interest in recent years, but its prospects hinge on answers to unresolved questions concerning the epistemological details of the account and the scope of its ambitions. (shrink)

Background Immense volumes of personal health information are required to realize the anticipated benefits of artificial intelligence in clinical medicine. To maintain public trust in medical research, consent policies must evolve to reflect contemporary patient preferences. Methods Patients were invited to complete a 27-item survey focusing on: broad versus specific consent; opt-in versus opt-out approaches; comfort level sharing with different recipients; attitudes towards commercialization; and options to track PHI use and study results. Results 222 participants were included in the analysis; (...) 83% were comfortable sharing PHI with researchers at their own hospital, although younger patients were more uncomfortable than older patients. While 56% of patients preferred broad consent, 38% preferred specific consent; 6% preferred not sharing at all. The majority of patients preferred to be asked for permission before entry into a contact pool. Again, this trend was more pronounced for younger patients. Approximately half of patients were uncomfortable sharing PHI with commercial enterprises. Most patients preferred to track PHI usage, with the highest proportion once again reported by the youngest patients. A majority of patients also wished to be notified regarding study results. Conclusions While most patients were willing to share their PHI with researchers within their own institution, many preferred a transparent and reciprocal consent process. These data also suggest a generational shift, wherein younger patients preferred more specific consent options. Modernizing consent policies to reflect increased autonomy is crucial in fostering sustained public engagement with medical research. (shrink)

Is there a sense in which we exercise direct volitional control over our beliefs? Most agree that there is not, but discussions tend to focus on control in forming a belief. The focus here is on sustaining a belief over time in the face of ‘epistemic temptation’ to abandon it. It is argued that we do have a capacity for ‘doxastic self-control’ over time that is partly volitional in nature, and that its exercise is rationally permissible.

What makes identity politics a significant departure from earlier, pre-identitarian forms of the politics of recognition is its demand for recognition on the basis of the very grounds on which recognition has previously been denied: it is qua women, qua blacks, qua lesbians that groups demand recognition.... The demand is not for inclusion within the fold of “universal humankind,” on the basis of shared human attributes; nor is it for respect “in spite of” one’s differences. Rather, what is demanded is (...) respect for oneself as different. And here we reach the crux of the matter: once we move from group claims to the individual struggle for recognition, to the continuous conversation with others and.. (shrink)

“Recognition” has become a keyword of our time. Yet this word [recognition] runs insistently through my readings, appearing sometimes like a gremlin who pops up at the wrong place, at other times as welcomed, even as looked for and anticipated. Which places are those? Recognition demands our attention. As a “keyword,” its significance is measured in part simply by the number of times it appears across the pages of the works that occupy our desks. Claimed by political theorists, moral philosophers, (...) cultural anthropologists, legal scholars, activists, historians, and rhetoricians, recognition has become a workhorse for theorizing the ontological, epistemological.. (shrink)

This article argues, contra-Derrida, that Foucault does not essentialize or precomprehend the meaning of life or bio- in his writings on biopolitics. Instead, Foucault problematizes life and provokes genealogical questions about the meaning of modernity more broadly. In The Order of Things, the 1974-75 lecture course at the Collège de France, and Herculine Barbin, the monster is an important figure of the uncertain shape of modernity and its entangled problems (life, sex, madness, criminality, etc). Engaging Foucault’s monsters, I show that (...) the problematization of life is far from a “desire for a threshold,” à la Derrida. It is a spur to interrogating and critiquing thresholds, a fraught question mark where we have “something to do.” As Foucault puts it in “The Lives of Infamous Men,” it an ambiguous frontier where beings lived and died and they appear to us “because of an encounter with power which, in striking down a life and turning it to ashes, makes it emerge, like a flash [...]. (shrink)

Background Rapid ethical access to personal health information to support research is extremely important during pandemics, yet little is known regarding patient preferences for consent during such crises. This follow-up study sought to ascertain whether there were differences in consent preferences between pre-pandemic times compared to during Wave 1 of the COVID-19 global pandemic, and to better understand the reasons behind these preferences. Methods A total of 183 patients in the pandemic cohort completed the survey via email, and responses were (...) compared to the distinct pre-pandemic cohort ; all were patients of a large Canadian cancer center. The survey covered broad versus study-specific consent; opt-in versus opt-out contact approach; levels of comfort sharing with different recipients; perceptions of commercialization; and options to track use of information and be notified of results. Four focus groups were subsequently conducted to elucidate reasons motivating dominant preferences. Results Patients in the pandemic cohort were significantly more comfortable with sharing all information and biological samples, sharing information with the health care institution, sharing information with researchers at other hospitals, sharing PHI provincially, nationally and internationally compared to the pre-pandemic cohort. Discomfort with sharing information with commercial companies remained unchanged between the two cohorts. Significantly more pandemic cohort patients expressed a wish to track use of PHI, and to be notified of results. Thematic analysis uncovered that transparency was strongly desired on outside PHI use, particularly when commercialization was involved. Conclusions In pandemic times, patients were more comfortable sharing information with all parties, except with commercial entities, where levels of discomfort remained unchanged. Focus groups identified that the ability to track and receive results of studies using one’s PHI is an important way to reduce discomfort and increase trust. These findings meaningfully inform wider discussions on the use of personal health information for research during global crises. (shrink)

The attitude of intention is not usually the primary focus in philosophical work on self-knowledge. A recent exception is the so-called “Transparency” theory of self-knowledge, which attempts to explain how we know our own minds by appeal to reflection on non-mental facts. Transparency theories are attractive in light of their relative psychological economy compared to views that must posit a dedicated mechanism of ‘inner sense’. However, it is argued here, focusing on proposals by Richard Moran and Alex Byrne, that the (...) Transparency approach to explaining knowledge of our intentions fails. Considerations of economy therefore recommend an alternative approach: the Rylean Theory Theory. The particular view defended here is that one way of coming to know what we intend is to self-ascribe an intention on the basis of making a conscious decision about what to do. This view requires that there are such things as conscious decisions, and so the existence of conscious decisions is defended against skeptical worries raised by Peter Carruthers. The conclusion is that we know of our intentions by theorizing about ourselves, but that this knowledge can still be first-personally privileged, authoritative, and non-alienated. (shrink)

ABSTRACT This essay walks through the ways the pandemic structures and limits our movement in cities. It suggests that our well-worn tropes for walking, in this moment, shore up the power of the state over individual bodies. To imagine the possibility of how bodily movement might resist this power, the essay turns to a rhetorical conception of scale.

This article argues, contra-Derrida, that Foucault does not essentialize or pre-comprehend the meaning of life or bio- in his writings on biopolitics. Instead, Foucault problematizes life and provokes genealogical questions about the meaning of modernity more broadly. In The Order of Things, the 1974-75 lecture course at the Collège de France, and Herculine Barbin, the monster is an important figure of the uncertain shape of modernity and its entangled problems. Engaging Foucault’s monsters, I show that the problematization of life is (...) far from a “desire for a threshold,” à la Derrida. It is a spur to interrogating and critiquing thresholds, a fraught question mark where we have “something to do.” As Foucault puts it in “The Lives of Infamous Men,” it an ambiguous frontier where beings lived and died and they appear to us “because of an encounter with power which, in striking down a life and turning it to ashes, makes it emerge, like a flash [...].”. (shrink)

Identifying the referent of novel words is a complex process that young children do with relative ease. When given multiple objects along with a novel word, children select the most novel item, sometimes retaining the word‐referent link. Prior work is inconsistent, however, on the role of object novelty. Two experiments examine 18‐month‐old children's performance on referent selection and retention with novel and known words. The results reveal a pervasive novelty bias on referent selection with both known and novel names and, (...) across individual children, a negative correlation between attention to novelty and retention of new word‐referent links. A computational model examines possible sources of the bias, suggesting novelty supports in‐the‐moment behavior but not retention. Together, results suggest that when lexical knowledge is weak, attention to novelty drives behavior, but alone does not sustain learning. Importantly, the results demonstrate that word learning may be driven, in part, by low‐level perceptual processes. (shrink)

My commentary focuses on Khalidi's defense of episodic memory as a cognitive kind. His argument relies on merging two distinct accounts of episodic memory—the phenomenal and the etiological. I suggest that Khalidi's framework can be used to carve the contemporary memory literature differently. On this view, the phenomenal account supports constructive episodic simulation as a cognitive kind, the etiological account supports event memory as a cognitive kind, and episodic memory ceases to be. The question for Khalidi is, then, how to (...) evaluate this alternative proposal—and more broadly how to adjudicate between competing and overlapping accounts of cognitive kinds. (shrink)

The practice of health-care professional involvement in capital punishment has come under scrutiny since the implementation of lethal injection as a method of execution, raising questions of the goals of medicine and the ethics of medicalized procedures. The American Medical Association and other professional associations have issued statements prohibiting physician involvement in capital punishment because medicine is dedicated to preserving life. I address the three primary arguments against health-care professionals being involved in lethal injection and argue that they are not (...) strong enough to prohibit physician involvement in the lethal injection process. (shrink)

Replication protein A (RPA) is the main eukaryotic single‐stranded DNA (ssDNA) binding protein, having essential roles in all DNA metabolic reactions involving ssDNA. RPA binds ssDNA with high affinity, thereby preventing the formation of secondary structures and protecting ssDNA from the action of nucleases, and directly interacts with other DNA processing proteins. Here, we discuss recent results supporting the idea that one function of RPA is to prevent annealing between short repeats that can lead to chromosome rearrangements by microhomology‐mediated end (...) joining or the formation of hairpin structures that are substrates for structure‐selective nucleases. We suggest that replication fork catastrophe caused by depletion of RPA could result from cleavage of secondary structures by nucleases, and that failure to cleave hairpin structures formed at DNA ends could lead to gene amplification. These studies highlight the important role RPA plays in maintaining genome integrity. (shrink)